Kohei Shitara Selected Research

Combination Drug Therapy (Combination Chemotherapy)

4/2023	A plain language summary of the CheckMate 649 study: nivolumab in combination with chemotherapy compared to chemotherapy alone for untreated advanced or metastatic cancer of the stomach or esophagus.
1/2020	Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer.
6/2013	A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric cancer.
1/2013	Fluoropyrimidine plus cisplatin for patients with advanced or recurrent gastric cancer with peritoneal metastasis.
7/2012	Combination chemotherapy with S-1 plus cisplatin for gastric cancer that recurs after adjuvant chemotherapy with S-1: multi-institutional retrospective analysis.
4/2012	Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for wild-type KRAS metastatic colorectal cancer refractory to irinotecan, oxaliplatin, and fluoropyrimidines.
12/2011	A case of heavily pretreated rectal cancer with disseminated intravascular coagulation that improved following reintroduction of FOLFOX plus bevacizumab.
12/2011	Sensitivity to previous irinotecan treatment does not predict the efficacy of combination chemotherapy with cetuximab plus irinotecan for wild-type KRAS metastatic colorectal cancer.
8/2011	Phase II study of combination chemotherapy with irinotecan and cetuximab for pretreated metastatic colorectal cancer harboring wild-type KRAS.
7/2011	FOLFOX plus cetuximab for a patient with metastatic colorectal cancer with icterus due to multiple liver metastases.

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Kohei Shitara Research Topics

Disease

145	Neoplasms (Cancer) 03/2024 - 01/2008
143	Stomach Neoplasms (Stomach Cancer) 05/2024 - 10/2005
52	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 12/2005
43	Adenocarcinoma 02/2024 - 09/2011
32	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2006
14	Disease Progression 12/2023 - 05/2011
14	Neutropenia 01/2023 - 02/2011
9	Esophageal Neoplasms (Esophageal Cancer) 10/2023 - 08/2006
8	Microsatellite Instability 01/2023 - 01/2021
7	Pneumonia (Pneumonitis) 12/2023 - 01/2006
7	Interstitial Lung Diseases (Interstitial Lung Disease) 11/2023 - 01/2006
6	Ascites 01/2022 - 11/2009
6	Breast Neoplasms (Breast Cancer) 01/2021 - 07/2006
6	Anemia 01/2021 - 06/2007
5	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2023 - 12/2005
4	Febrile Neutropenia 01/2022 - 01/2017
4	Fever (Fevers) 12/2021 - 01/2006
4	Colonic Neoplasms (Colon Cancer) 07/2011 - 07/2007
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2024 - 09/2017
3	Acute Kidney Injury (Acute Renal Failure) 12/2023 - 01/2017
3	Exanthema (Rash) 01/2023 - 01/2020
3	Fatigue 12/2021 - 07/2011
3	Rectal Neoplasms (Rectal Cancer) 04/2021 - 07/2008
3	Thrombocytopenia (Thrombopenia) 01/2021 - 08/2011
3	Leukopenia 01/2020 - 08/2011
3	Hemorrhage 01/2018 - 08/2015
3	Jaundice (Icterus) 08/2011 - 07/2009
3	Dyspnea (Shortness of Breath) 03/2011 - 01/2006
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2008 - 11/2005
2	Melanoma (Melanoma, Malignant) 01/2024 - 09/2017
2	Colitis 12/2023 - 10/2006
2	Nausea 12/2023 - 12/2023
2	Sepsis (Septicemia) 12/2023 - 01/2022
2	Turcot syndrome 08/2023 - 05/2017

Drug/Important Bio-Agent (IBA)

31	pembrolizumabIBA 01/2024 - 01/2018
25	Immune Checkpoint InhibitorsIBA 02/2024 - 09/2017
24	Biomarkers (Surrogate Marker)IBA 05/2024 - 06/2012
22	Monoclonal AntibodiesIBA 01/2024 - 10/2016
22	Oxaliplatin (Eloxatin)FDA LinkGeneric 11/2023 - 12/2005
21	NivolumabIBA 02/2024 - 01/2019
20	Trastuzumab (Herceptin)FDA Link 12/2023 - 07/2006
20	Paclitaxel (Taxol)FDA LinkGeneric 01/2023 - 01/2006
20	Irinotecan (Camptosar)FDA LinkGeneric 01/2020 - 10/2005
18	trifluridine tipiracil drug combinationIBA 02/2024 - 01/2016
18	Cisplatin (Platino)FDA LinkGeneric 12/2023 - 08/2006
18	human ERBB2 proteinIBA 12/2023 - 05/2011
17	Bevacizumab (Avastin)FDA Link 03/2024 - 07/2008
16	Fluorouracil (Carac)FDA LinkGeneric 01/2023 - 12/2005
13	trastuzumab deruxtecanIBA 05/2024 - 01/2019
13	RamucirumabIBA 11/2023 - 02/2015
13	Cetuximab (Erbitux)FDA Link 01/2020 - 04/2009
10	ErbB Receptors (EGF Receptor)IBA 05/2024 - 04/2015
9	B7-H1 AntigenIBA 09/2023 - 10/2018
9	Leucovorin (Folinic Acid)FDA Link 01/2023 - 07/2007
9	Capecitabine (Xeloda)FDA Link 01/2023 - 12/2005
9	Docetaxel (Taxotere)FDA Link 12/2021 - 11/2006
8	regorafenibIBA 02/2024 - 12/2016
8	PlatinumIBA 12/2023 - 07/2007
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2023 - 02/2015
7	LigandsIBA 08/2023 - 05/2017
6	zolbetuximabIBA 03/2024 - 01/2023
6	Panitumumab (Vectibix)FDA Link 02/2024 - 04/2009
6	S-1 plus cisplatinIBA 01/2016 - 11/2010
5	Immunoconjugates (Immunoconjugate)IBA 03/2024 - 11/2017
5	AntibodiesIBA 03/2024 - 05/2017
4	Epidermal Growth Factor (EGF)IBA 02/2024 - 07/2012
4	DNA (Deoxyribonucleic Acid)IBA 10/2023 - 06/2018
4	Cytotoxins (Cytolysins)IBA 10/2021 - 06/2011
4	taxaneIBA 02/2020 - 06/2006
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2020 - 02/2015
3	RNA (Ribonucleic Acid)IBA 02/2024 - 01/2022
3	TAS-116IBA 02/2024 - 01/2019
3	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2019
3	Phosphotransferases (Kinase)IBA 05/2023 - 01/2019
3	eribulin FDA Link 01/2023 - 01/2023
3	napabucasinIBA 07/2022 - 05/2019
3	lenvatinibIBA 01/2022 - 01/2020
3	Circulating Tumor DNAIBA 10/2021 - 12/2016
3	Taxoids (Taxanes)IBA 03/2021 - 06/2011
3	Ado-Trastuzumab EmtansineIBA 02/2020 - 10/2016
3	130-nm albumin-bound paclitaxelIBA 01/2019 - 01/2017
3	Gemcitabine FDA Link 01/2017 - 11/2005
3	thiamine triphosphorate (TTP)IBA 04/2014 - 07/2007
2	ClaudinsIBA 03/2024 - 10/2023
2	Antineoplastic Agents (Antineoplastics)IBA 02/2024 - 01/2010
2	Complement System Proteins (Complement)IBA 01/2024 - 10/2023
2	Immunoglobulin G (IgG)IBA 10/2023 - 01/2019
2	IpilimumabIBA 01/2023 - 01/2022

Therapy/Procedure

122	Drug Therapy (Chemotherapy) 03/2024 - 12/2005
78	Therapeutics 03/2024 - 10/2005
20	Combination Drug Therapy (Combination Chemotherapy) 04/2023 - 07/2006
15	Immunotherapy 02/2024 - 01/2018
12	Adjuvant Chemotherapy 12/2023 - 11/2008
9	Gastrectomy 08/2023 - 10/2007
7	Precision Medicine 03/2021 - 09/2018
7	Radiotherapy 01/2020 - 06/2007
6	Chemoradiotherapy 11/2012 - 08/2006
4	Neoadjuvant Therapy 11/2023 - 10/2007
4	Lymph Node Excision (Lymph Node Dissection) 01/2020 - 07/2006
3	Aftercare (After-Treatment) 01/2018 - 07/2007